A friend of mine asked for some war stories of entrepreneurship over a couple of beers.
My best advice was to point him in the direction of Eric Ries super book, almost a manual, certainly a must-read ... The Lean Startup.
At its heart, though, my experience is one of focusing on a few simple principles:
In addition to the necessary and sufficient test, and turning Weaknesses into Strengths, we actively use our geography to help us. And it's really all about having the right attitude.
We can see problems as obstacles, or as hurdles to be overcome. I no longer expect problems to disappear, but to change and be replaced by new things. Provided that the challenges are changing then, crudely, we're making progress!